This project utilizes an ongoing Dongfeng-Tongji longitudinal cohort to study the determinants of chronic diseases, especially air pollution and lifestyle factors. Launched in 2008, the cohort has developed a detailed database that incorporates demographic, lifestyle, and biochemical information of about 27,000 retired workers of Dongfeng Motor Corporation, a giant state-owned motor company. The project will assess environmental exposure, lifestyle factors, and biochemical markers to examine the association of health outcomes with air pollution and lifestyle factors.